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KMID : 0882420140870040491
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Korean Journal of Medicine
2014 Volume.87 No. 4 p.491 ~ p.495
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A Case of Acute Tubular Necrosis and Hearing Loss Induced by Intravenous Administration of Ciprofloxacin
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Kim Jun-Jae
Kim Hyun-Jung
Kim Sang-Hyun
Park Won-Do
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Abstract
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Ciprofloxacin is a broad-spectrum antibiotic used to treat a variety of infections. However, acute kidney injury is a rarely reported side effect. Ciprofloxacin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. To the best of our knowledge, few cases of acute tubular necrosis as a complication of ciprofloxacin have been reported to date. We herein describe a case involving a 41-year-old woman treated with intravenous ciprofloxacin at 200 mg twice daily for gastroenteritis. One day after initiation of treatment, her serum creatinine level increased from 0.95 to 3.83 mg/dL and she experienced impaired hearing. Five days later, renal biopsy demonstrated acute tubular necrosis. The acute tubular necrosis encountered in this patient resolved; however, short-term hemodialysis was required. This is the first reported case of acute kidney injury associated with ciprofloxacin use in Korea
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KEYWORD
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Ciprofloxacin, Acute kidney injury, Acute tubular necrosis, Hearing loss
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